All the information below is strictly for research purposes only. Under no circumstance should this chemical be used for human consumption.
Adipotide is a peptidomimetic substance with a structural sequence of CKGGRAKDC-GG-D(KLAKLAK)2. Adipotide selectively acts and shrinks the adipose tissue fat supplying blood vessels and induce apoptosis. In primates and rodents, Adipotide significantly induce weight loss by rapid fat elimination. The compound directly acts on fat cells due to high affinity towards two receptors such as prohibitin and ANXA2. The investigative compound was developed by a team of US scientists; intended only for research applications.
Clinical studies reveal that adipotide is able to cause adipocytes apoptosis, which in turn causes reduction in mass, and volume and mass of the subcutaneous fat. The hormone causes a programmed cell death by depriving them nutrients and this cause cellular atrophy. Moreover in the mitochondrial cascade to increase the production of proteins from the amino acids while reducing fat cells.
Research shows that the adipotide kills fat cells by selectively causing a programmed cell death or apoptosis. When the fat cells are deprived of nutrients, they die of starvation and causing the release of the enzymes referred to as caspases in which are the enzymes that initiate programmed cell death. Adipotide acts on ANXA-2 and prohibitin receptors, these are cell surface receptors located in the endothelial wall and the vessels supply blood to white adipocytes. The formation of white adipocytes often occurs when the energy consumption is less than utilization, this leads to the conversion of the excess energy to fats for storage. Obesity is a key aspect in development of a myriad of diseases such as myocardial infarctions and degenerative diseases. Abdominal obesity is often associated with white adipocytes.
Molecular weight: 2555.22
Peptide purity: > 99.0%
What is Adipotide?
Adipotide is a peptidomimetic substance with a structural sequence of CKGGRAKDC-GG-D (KLAKLAK) 2. Adipotide selectively acts and shrinks the adipose tissue fat supplying blood vessels and induce apoptosis. In primates and rodents, Adipotide significantly induces weight loss by rapid fat elimination. The compound directly acts on fat cells due to high affinity towards two receptors such as prohibitin and ANXA2. The investigative compound was developed by a team of US scientists; intended only for research applications.
Clinical studies reveal that adipotide is able to cause adipocytes apoptosis, which in turn causes a reduction in mass and volume and mass of the subcutaneous fat. The hormone causes a programmed cell death by depriving them nutrients and this cause cellular atrophy. Moreover in the mitochondrial cascade to increase the production of proteins from the amino acids while reducing fat cells.
myriad of diseases such as myocardial infarctions and degenerative diseases. Abdominal obesity is often associated with white adipocytes.
Recent studies revealed that the peptide-like the mechanism of action is via the denaturation of the adipocytes or the fat cells on the peripheral and visceral organs. This is essential because it causes a dramatic decrease in the volume and mass of the subcutaneous deposits. Adipotide is known to cause cell death through various mechanisms. First, it initiates a programmed cell death or a process referred scientifically as apoptosis. Adipotide reduces uptake of nutrients and blood supply to the fat cells. Depriving the fat cells of nutrients and blood supply results in cell death and it is excreted as waste material. The irreversible process causes the release of mitochondrial enzymes mainly protease caspase which plays an important role in accentuating cell death. When apoptosis is initiated, it prompts the activation of transcription. Transcription is a process where deoxyribonucleic acid is used in creating messenger RNA and messenger RNA is used as a template in creating a nascent peptide of the genetic sequence. The genetic sequence codes for proteins and it has a net effect on the cell death. Molecular research studies show that the adipotide process is unique to three-stereochemical conformation. This allows it to bind to various multiple receptors ANXA-2 and prohibitin. These receptors are found on the endothelial surface of blood vessels that supply the fat cells with blood and nutrients.
Research studies are focused on the cell surface receptors of the adipocytes and this will help in reducing the fat cells on the peripheral and visceral organs considerably. Formation of white adipocytes usually occurs when the consumption of energy is lower than the supply. This results in an oversupply and the excess energy is stored as glycogen and fat then stored in the peripheral cells. Pathological research showed that obesity is the main contributor of various ailments such as degenerative diseases, cardiovascular diseases, endocrine diseases, hypertension, cancer, and myocardial infarction. Moreover, an aberrant accumulation of the white adipocytes on peripheral cells predisposes the subject to lipoma and lipomatosis. Studies revealed that adiposity is exaggerated when white adipocytes are in large numbers. Adipocytes are lipolytically active and they will encourage the transfer of the fat cells to the peripheral organs.
When apoptosis is initiated, it plays an essential role in the alleviation of the white adipocytes in the peripheral and visceral organs. Studies revealed that adipotide binds to the cell surface of the adipocytes and this prevent nourishing and blood supply to the fat cells. Prohibitin also called PHB is a complex protein that is coded by PHB gene. This peptide plays an integral part in inhibiting DNA synthesis and cell proliferation. A higher level of prohibitin overcomes the overall effects of adiposity.
How Does Adipotide Contribute To Weight Loss?
Recent research studies showed that adipotide plays an integral part in alleviating excess fats from the peripheral and visceral organs. This is an important process because it contributes to weight loss. According to the studies, adipotide is classified as a peptidomimetic and when it is administered to the research mice. The mice showed weight reduction and placebo showed no weight loss, the mechanism of action is via the truncation and inhibiting the supply of blood and nutrients to the fat cells. Once these cells are deprived of nutrients and blood supply they die off and are excreted through the natural excretion process. The findings indicate that research mice lost about 11% of the total weight. This is a considerable amount of weight especially when it is considered that the time span was less. The chains of adipotide stimulate a natural weight loss
During the studies, the mice were injected with the peptide and the results of the findings monitored closely. The changes in the body mass and the deposition of fats in the peripheral organs was the main objective of the research. It is important to note that the peptide has a modern and biologically active system. This aids in cutting the supply of blood and nutrients to the adipocytes or fat cells. Activation of this signaling cascade enhances the functionality of the peptide and once these fat cells are killed it results in a reduction of subcutaneous fat cells and thereby weight loss. Adipotide is efficient in its mode of action because it accentuates programmed cellular death. A programmed cellular death is more effective in accentuating weight loss because it tends to avoid induction of a sudden weight loss. Adipotide has several domains and all these domains work in synergy to accentuate weight loss. It is important to note that these domains can work in synergy or as a single entity to induce weight loss.
The first domain is called homing domain and this is vital because it works by targeting membrane associated protein. Prohibitin is a membrane-associated protein and it is vital in accentuating weight loss. Homing domain works by killing the adipocytes on the endothelial matter and this accentuates overall weight loss. When the fat cells shrink off weight, loss occurs and this is essential because for any organism lose of peripheral and visceral fat is important. The second domain is membrane-disrupting domain and this accentuates cellular death by stopping mitochondrial membrane activity within targeted cells. When cells are deprived of nutrients and blood supply, they begin to wear out and die off eventually. Research experiments show that there is a possibility of utilizing this peptide in accentuating weight loss.
Current research shows that adipotide should be administered daily in order to get the desired result. In most cases, having a significant weight loss cannot be achieved without a regular dosage. According to the study administration of the adipotide resulted in a 20% decrease in the total weight of the test subject. This is a quite significant weight loss because it accounts for more or close to a fifth of the total weight. However, there are other factors that come into play and these include environment, body condition, and the presence of hormone leptin. Leptin is a peptide that signals satiety, when the level of this hormone is low it increases weight gain because the test subject does not respond to a full stomach. However, a high content of leptin accentuates a feeling of satiety and this is vital because the organism will consume less food and therefore low weight gain.
Activation of leptin receptors is important because it results in weight loss. When these receptors are activated, the test subject will respond to a volume of food ingested to the system and this is vital in accentuating weight loss. Dead fat cells are metabolized and released from the system as waste. Once the peptide was administered, the test subjects are allowed four weeks to recover from the effects and it helps the biological system to cope up with changes. Monitoring recovery phase is crucial because it will determine the context of weight loss. Although the peptide is supplied in the market, it is solely for research purposes only and the potential benefits seem appealing. The adipotide enhances production of hormones in the system, production of growth hormone adipotide peptide triggers a wide array of psychological symptoms that does not affect neurotransmitters, and it accentuates relay of information from the brain to the central nervous system. Adipose is very effective in accentuating cellular death and research shows that it could serve as one of the peptides to accentuate weight loss in the end. However, further research should be undertaken to determine its efficacy and potency before use in other areas.