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CJC-1295 (DAC)

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CJC-1295 (DAC)

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$20.99
Description

What is CJC-1295 with DAC?


All the information below is strictly for research purposes only. Under no circumstance should this chemical be used for human consumption.


CJC-1295 (DAC) belongs to tetra-substituted peptide hormones classification. CJC-1295 (DAC) contains 30 amino acids. The modified version of GRF 1-29 demonstrates a high affinity towards GHRH receptors. The molecular weight of CJC-1295 (DAC) is 3647.28 and molecular formula is C165H269N47O46. The compound was originally developed by a team of Canadian researchers to increase half-life of growth hormone releasing hormone. Research studies confirmed that the synthetic complex increases GHRH and IGF-1 secretion but not prolactin. CJC-1295 promotes lipolysis and protein biosynthesis. The biomolecule arrangement of CJC-1295 (DAC) prevents rapid degradation and improves half-life. The compound is being studied successfully since the 2000’s due to visceral fat degrading properties. The relative half-life of the compound is 5.8-8.1 days. However, addition of IGF-1 may increase the half-life up to 30 days. Further studies are being conducted to explore the benefits of CJC 1295 (DAC) on deep sleep or slow wave of the brain. 


Growth hormone and somatostatin are released in pulses in the anterior lobe of the pituitary gland, to counter the effects of somatostatin the level of CJC-1295 DAC should be kept at a high level throughout. Studies conducted in the past two decades led to the introduction of different growth hormone secretagogues. However, more research is being conducted to ascertain the effectiveness and efficacy of the hormone. Moreover, an enhanced level of growth hormone in the system has a positive effect in fat metabolism. CJC-1295 DAC has a positive feedback mechanism on the production of Ghrelin a hormone known to induce feelings of hunger, gastric emptying, and motility. Further studies reveal that a combined blend of the polypeptide with growth hormone hexapapeptide increases the rate of release of IGF-1 without any considerable effect on prolactin. The main feature of the polypeptide is the existence of the DAC or drug affinity complex, which is formed from lysine binding to maleimidoproprionic acid.


CJC-1295 DAC Chemical Profile


CAS: 863288-34-0
Formula: C165H269N47O46
Molecular weight: 3647.28
Peptide purity: > 99.0%
Chain: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionyl)-NH2







What is CJC-1295 with DAC?



CJC-1295 (DAC) belongs to tetra-substituted peptide hormones classification. CJC-1295 (DAC) contains 30 amino acids. The modified version of GRF 1-29 demonstrates a high affinity towards GHRH receptors. The molecular weight of CJC-1295 (DAC) is 3647.28 and molecular formula is C165H269N47O46. The compound was originally developed by a team of Canadian researchers to increase half-life of growth hormone releasing hormone. Research studies confirmed that the synthetic complex increases GHRH and IGF-1 secretion but not prolactin. CJC-1295 promotes lipolysis and protein biosynthesis. The biomolecules arrangement of CJC-1295 (DAC) prevents rapid degradation and improves half-life. The compound is being studied successfully since the 2000’s due to visceral fat degrading properties. The relative half-life of the compound is 5.8-8.1 days. However, addition of IGF-1 may increase the half-life up to 30 days. Further studies are being conducted to explore the benefits of CJC 1295 (DAC) on deep sleep or slow wave of the brain.



Growth hormone and somatostatin are released in pulses in the anterior lobe of the pituitary gland, to counter the effects of somatostatin the level of CJC-1295 DAC should be kept at a high level throughout. Studies conducted in the past two decades led to the introduction of different growth hormone secretagogues. However, more research is being conducted to ascertain the effectiveness and efficacy of the hormone. Moreover, an enhanced level of growth hormone in the system has a positive effect in fat metabolism. CJC-1295 DAC has a positive feedback mechanism on the production of Ghrelin a hormone known to induce feelings of hunger, gastric emptying, and motility. Further studies reveal that a combined blend of the polypeptide with growth hormone hexapapeptide increases the rate of release of IGF-1 without any considerable effect on prolactin. The main feature of the polypeptide is the existence of the DAC or drug affinity complex, which is formed from lysine binding to maleimidoproprionic acid.



Moreover, CJC DAC is known to work in synergy with growth hormone releasing hormone to accentuate release of growth hormone from somatotrophs on the anterior lobe of the pituitary gland. The peptide is known to increase sensitivity to receptors and it increases growth hormone per somatotrope. Recent research studies shows that when the peptide is mixed with growth hormone releasing hexapeptide it accentuates a release of growth hormone from anterior lobe of pituitary gland. This is beneficial because the amplitude per cell increases rapidly and this plays an essential role in reducing somatostatin pulses. Somatostatin is a hormone that is produce at the same pulse with growth hormone. When production of somatostatin is high the levels of growth hormone is low and vice versa. Therefore, it is essential to keep the levels of somatostatin at its lowest level to avoid low production of growth hormone. Studies reveal that the presence of GH in the system does not affect the levels of insulin like growth factor 1 and prolactin in the system. The potency and efficacy of these peptides are still under research and it is essential to monitor progress and peptide functionality when administering to research test subjects.





CJC DAC has drug affinity complex or DAC, this part of the peptide is essential because it presents the ligand binding aspect of the peptide. Configuration structure and orientation of the peptide plays an important role in presenting the peptide in the right direction and binding abilities of the peptide. In addition, it prevents the degradation of peptide by adding another cushion or layer that enhances its functionality. During this activity maleimidoproprionic, acid binds to amino acid lysine that is located on drug affinity complex and this is the most reactive amino acid in the chain. When the binding occurs CJC DAC molecule undergoes changes to accentuate its effects on a biological system. CJC DAC is the most essential peptides in releasing growth hormone from anterior lobe of pituitary gland. However, the difference between CJC 1295 DAC and CJC 1295 is that the latter does not have drug affinity complex. Sermorelin or modified growth factor 1-29 has a half-life of 7 days and increase in hormonal secretion poses a major threat in its functionality. It should be understood that the working principle is via modification of various ligand to receptor binding.



Important changes that occur on amino acid number 27,15,8 and 2 are crucial in increasing the functionality and the binding ability of the peptide. Amino acids leucine, alanine, glutamine, and D-alanine are substituted and they aid in overall functionality of the peptide. Polypeptides are amino acids which are linked together through amide bonds and they differ in configuration some are linear while others are cyclic. It is important to understand protein structure in order to know how binding to different receptors and the mode of action varies greatly. There are four structural types and these include quaternary, tertiary, secondary, and primary structures. Primary structure is the simplest and it is made up of amino acids linked to each other in a linear manner. Secondary structures encompass primary structures linked together to from folded sequence. On the other hand, tertiary structures are composed of complex protein structure that includes various amino acids folded together in a complex sequence that it’s quite difficult to determine the origin.



Complexity of protein structures determines its binding abilities because the ligand to receptor binding feature should be presented in a modern fashion for overall functionality to be enhanced. It is important to understand protein structure because it plays a role in how amino acids bind to one another in a biological system.



Difference between CJC 1295 DAC and CJC 1295



CJC without dac is a polypeptide that is made up of thirty amino acids in its sequence and it is classified as a growth hormone releasing secretagogue. Essentially, it is imperative to know that the peptide accentuates release of growth hormone from anterior lobe of pituitary gland in larger pulses. Natural growth releasing hormone usually releases the peptide but in smaller pulses or amplitude. The peptide has shown an increased efficacy in aiding injury recovery among other potential benefits as well. In some findings, CJC DAC has the ability to reduce deposition of fats on peripheral and visceral organ. Studies showed that injection of the peptide to obese mice resulted in a significant weight loss. In addition, the peptide increases bone density and it helps in enhancing cellular repair on the skin. Studies reveal that it works in synergy with growth hormone releasing peptide to accentuate release of growth hormone from somatotrophs.



Although these two peptides have ability to work individually, it is imperative to understand that release of growth hormone from somatotrophs usually occurs when growth hormone releasing hormone is released at higher amplitude than somatostatin. There have been numerous studies that look at functionality of peptides and it reveals that muscle building is one of the aspects of modern research. Development, multiplication, and maturity of muscle cells depend on the functionality of CJC peptide. It is important to note that the tetra-substituted version of sermorelin is a more potent of the peptide because it releases growth hormone at a constant volume within a certain period. The half-life of original peptide depends on the orientation of various molecules in the sequence. The peptide is modified biological to enhance sensitivity and biological activity in the system and studies reveals that it reduces metabolic clearance rate of CJC while increasing binding affinity.



Drug affinity complex is crucial in enhancing its bioavailability and potency of the peptide. Modification of the peptide has shown to be effective in enhancing its functionality and efficacy. Recent studies reveal that peptide availability and functions are enhanced greatly with administration of CJC peptide. When this peptide is combined with growth hormone releasing hormone they synergistically combine and work to accentuate release of growth hormone from pituitary gland. Research shows that this peptide can be active for 7-10 days depending on the present enzymes and other degrading enzymes in the system. Drug affinity complex allow the peptide to move from one region to another without degradation and it will present the peptide in the right configuration to bind to receptor. The naming of these peptides can be confusing, however noting the functionality and how it works is imperative in knowing how it works.



In most cases, the peptide is supplied as freeze-dried vial. Supplied as a freeze dried vial or lyophilized powder the peptide should be reconstituted with bacteriostatic or saline water. This is an important part of any research because it prevents contamination of the vials by any pathogen or bacteria. You should leave lyophilized vial to thaw at room temperature because increasing temperature rapidly will affect peptide functionality as it alters the amino acid configuration and binding features. The recommended dosage is 1 mg to 2mg and this showed a major effect on the test organism. Studies shows that peptide is vital in increasing the amount of growth hormone released , the use of growth hormone in reducing or alleviating various effects is still in research and currently peptides supplied is solely for research purposes only. In adults, the production of GH reduces gradually when they begin ageing, in most cases, the main cause is the failure of the receptors to recognize the hormone and in some cases, and it is the failure of the somatotropes to produce the required amounts of the peptide.