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CJC-1295 (NO DAC)

CJC-1295 (no dac) 2mg

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  • CJC-1295 (no dac) 2mg
  • CJC-1295 (no dac) 5mg research chemical

CJC-1295 (NO DAC)

Availability: In stock

$19.95

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$19.95
Description

What is CJC-1295?


All the information below is strictly for research purposes only. Under no circumstance should this chemical be used for human consumption.


CJC-1295, a modified form of GRF 1-29 NO DAC, is a peptide hormone that contains 29 amino acids. Since the 2000’s, the compound has been studied to explore the lipolytic properties, particularly the visceral fat elimination. The compound is able to conjugate with serum albumin, thereby increasing the half-life and therapeutic potential. CJC-1295 stimulates the pituitary gland, and promotes protein biosynthesis. Research suggests CJC-1295 might increase secretion of growth hormones and IGF-1 but not prolactin. The molecular weight and formula of the compound is 3367.979 and C152H252N44O42, respectively.


The modified GRF 1-29 is a modified version of the growth hormone releasing factor with Gln, Ala, Leu, and D-Ala substituted on position 8, 15, 27, and 2, respectively. The substitution is important in creating a more stable peptide and each substitution plays a key role. Substitution at position 27 prevents the oxidation of methionine, position 15 enhances the bioactivity of the peptide, and position 8 reduces asparagines rearrangement while position 2 prevents the DPP-IV cleavage process. CJC-1295 and CJC-1295 DAC are both analogs of the growth hormone releasing hormone; their mode of action is similar, however, the main difference between the two peptides is the half-life. Many scientists consider Mod GRF 1-29 to be more natural because it stimulates the HGH release in a pulsatile manner. One of the studies on CJC -1295 indicates that the peak shown by the hormone is preferable for the immediate increase in GH, however a combined therapy is mostly recommended because it can balance the release of the hormone while inhibiting somatostatin, thereby increasing GH per somatotrope.


CJC-1295 Chemical Profile


CAS: 863288-34-0
Formula: C152H252N44O42
Molecular weight: 3367.2
Peptide purity: > 99.0%
Chain:Tyr-d-ALA-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2


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What is CJC-1295?



CJC-1295, a modified form of GRF 1-29 NO DAC, is a peptide hormone that contains 29 amino acids. Since the 2000’s, the compound has been studied to explore the lipolytic properties, particularly the visceral fat elimination. The compound is able to conjugate with serum albumin, thereby increasing the half-life and therapeutic potential. CJC-1295 stimulates the pituitary gland, and promotes protein biosynthesis. Research suggests CJC-1295 might increase secretion of growth hormones and IGF-1 but not prolactin. The molecular weight and formula of the compound is 3367.979 and C152H252N44O42, respectively.



The modified GRF 1-29 is a modified version of the growth hormone releasing factor with Gln, Ala, Leu, and D-Ala substituted on position 8, 15, 27, and 2, respectively. The substitution is important in creating a more stable peptide and each substitution plays a key role. Substitution at position 27 prevents the oxidation of methionine, position 15 enhances the bioactivity of the peptide, and position 8 reduces asparagines rearrangement while position 2 prevents the DPP-IV cleavage process. CJC-1295 and CJC-1295 DAC are both analogs of the growth hormone releasing hormone; their mode of action is similar, however, the main difference between the two peptides is the half-life. Many scientists consider Mod GRF 1-29 to be more natural because it stimulates the HGH release in a pulsatile manner. One of the studies on CJC -1295 indicates that the peak shown by the hormone is preferable for the immediate increase in GH, however a combined therapy is mostly recommended because it can balance the release of the hormone while inhibiting somatostatin, thereby increasing GH per somatotrope.



Cjc 1295 peptide is made up of thirty amino acids and it is imperative to know that is mode of action is via stimulation of various components in a biological system to release growth hormone. Growth hormone is important in accentuating cellular division, cell development, maturity, and replacement of death cells and tissues from various organs. Release of growth hormone alternates with somatostatin, when somatostatin is produced growth hormone is not produced. However, it is important to keep the levels of growth hormone releasing hormone at a higher level to prevent any cellular degradation of lack of functionality. Antagonism is a concept that should be clearly watched when accentuating the release of growth hormone. Somatostatin is a tough antagonist of growth hormone and it is released in pulses alongside growth hormone on somatotrophs. Studies show that CJC without DAC peptide is vital in accentuating the release of growth hormone. This is essential because it enhances release of growth hormone, pulsatile accentuation of growth hormone from pituitary gland is important in cell differentiation, cell division, and cell maturity.



Recent studies reveal that the peptide is important in increasing the rate of lipolysis. Lipolysis is an aspect where fat cells are broken down and this prevents deposition of fats on peripheral and visceral organs. It is imperative to understand that modern science is solely focused on natural and highly functional ways of increasing release of growth hormone from pituitary gland. Moreover, it accentuates an increase in ghrelin in the system. Ghrelin is a hormone that accentuates gastric motility and gastric emptying. It is important to note that gastric motility and gastric emptying is a vital phenomenon that helps in reducing fat deposition. Moreover, ghrelin is produced by the walls of the stomach in response to presence of food in the stomach. Formation of lipids in the stomach and deposition of fats on peripheral and visceral organs is the main source of weight gain. Deposition of fats contributes to weight gain and it is important that you consider amount of fats consumed at a sitting. According to a research study, Cjc is effective in preventing fat deposition.



According to recent studies, leptin is a hormone that signals satiety or a feeling of fullness of the stomach. Formation of lipids and deposition occurs when the body does not respond to leptin. Leptin resistance is the main cause of overweight and obesity, it is important to note that failure of receptors to bind to this hormone will aggravate various conditions. CJC peptide works in synergy with growth hormone releasing hormone in accentuating the release of growth hormone from the anterior lobe of the pituitary gland. Research shows that Cjc increases the sensitivity of the peptide to various peptides such as growth hormone. In addition, CJC increases release of growth per cell and this is important in overall functionality of cells and tissues. In addition, peptide blending is a new concept in the market and according to studies mixing various peptides with a certain concentration is vital to accentuate release of growth hormone. Growth hormone releasing hormone is vital in accentuating release of growth hormone from somatotrophs.



Recent studies indicated that CJC peptide does not affect the affects the level of insulin like growth factor 1 and prolactin levels respectively. Although this peptide does not have drug affinity complex, it is essential to note that it is effective in accentuating release of growth hormone from anterior lobe of pituitary gland. The presence of this peptide is crucial in inhibiting the production of somatostatin from anterior lobe of pituitary gland and blending it with growth hormone releasing hexapeptide or growth hormone releasing peptide 2 is vital in accentuating activities of maleimidoproprionic or MPA acid, which binds to lysine receptors on the peptide. CJC peptide is crucial in accentuating release of growth hormone from the anterior lobe of the pituitary gland and it is the second version of growth hormone. Peptides are linked together via amide bonds that are vital in determining orientation and presentation of ligand to the peptide.



The orientation and conformation of the peptide plays an important role in determining efficacy and potency of a peptide. Structure of protein accentuates its functionality in releasing growth hormone from anterior lobe of pituitary gland. The affinity binding should be stronger to bring about a net positive effect in accentuating release of growth hormone. Cjc without drug affinity complex is made up of thirty amino acids and the sequence plays an essential role in accentuating release of growth hormone. It is imperative to know that Cjc peptide accentuates production, development, and maturity of cells. This is crucial in replacing damaged or dead cells. Injury recovery process is faster especially in situation where the cells are damaged because of pressure or other factors that could cause damage to the cells/ the peptide works by increasing growth hormone per somatotroph and it works in synergy with other peptides to accentuate release of growth hormone.



Although the peptide has capacity to work on its own it is imperative to note that increasing amount of growth hormone per cell is the main objective of most researchers. Growth hormone released per cell depends on the accentuation and releasing abilities of the peptide. There have been various researches that have shown that it can increase amount of growth hormone per cell and muscle building. Myoblastic differentiation is an essential aspect in modern science because it increases muscle cells and prevents injuries. The tetra-substituted version is vital to accentuate release of growth hormone. Growth hormone releasing hormone has a quite an essential longer time considering that the hormone is endogenously produced. Endogenous production of peptide is affected by the concentration of various enzymes and proteases in the system. Experiments show that modification of the peptide is essential in increasing its activity and metabolic clearance is largely reduced. When the peptide is modified, it increases its efficacy and potency thereby presenting active or binding sites to the desired ligand.



Although the functionality of the peptide depends on drug affinity complex for the other counterpart is imperative to note that CJC DAC is effective in accentuating release of growth hormone from somatotrophs. Peptide modification is solely focused to enhance its potency and efficacy considering that it is prone to different lyses and degradation processes in a biological system. The half-life is extended by accentuating the binding sites ad this prevents any type of degradation of the peptide. Moreover, activity of CJC peptide is high and more effective than a regular one. The naming of CJC 1295 and CJC 1295 DAC can be quite confusing especially to novice. However, it is imperative to note that the latter has drug affinity complex, which is a compound that enhance the efficacy and potency of the peptide.



Research shows that peptide reconstitution should be done with bacteriostatic or saline water, this is essential because it reduces contamination and transfer of bacteria from the vials. It is important that you leave the peptide to thaw at room temperature increasing temperature rapidly will result in breaking of bonds and this will affect conformation and binding of the peptide. Just like other peptides, CJC 1295 is touted as one of the best peptide in accentuating release of growth hormone. The natural systemic release of growth hormone is slow and accentuating its release via administration of Cjc peptide. Regular dosage should be 0.1 mg to 0.2 mg and combining the vial with other peptides can help increase hormonal production.




 

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