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Follistatin 344 is an activin-binding protein that aid muscle repair process and also improve motor functions. It is is made up of 323 amino acids.
It binds directly with activin and acts as an activin antagonist. Follistatin 344 is a selective inhibitor of biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). Follistatin 344 is a potent myostatin inhibitor and promotes muscle growth this is due to the fact it blocks myostatin. The peptide is preferred by athletes who are unable to exercise regularly or opt out from sports activities but need massive muscle mass. Research studies demonstrated the anti-aging and tissue rejuvenation effects of Follistatin, it is also a glycoprotein encoded by the FST gene which means that it is widely distributed in all tissues. A single follistatin gene encodes to various isoforms including FST317 and FST344.
These isoforms are made up of 317 and 344 amino acids that promote alternative splicing of mRNA. Molecular biological studies have identified potential linkage between polycystic ovarian syndrome and follistatin genes. It was first discovered as follicle stimulating hormone compound in the ovarian follicle fluid. The human Follistatin CDNA encodes for a 344 amino acid protein with 29 amino acids signaling the sequence. The domain that encodes for the EGF has kazallike motifs and a highly acidic C-terminal. The secreted Follistatin binds to TGF-family ligand as indicated and it regulates the activity of the signaling receptors. Previous studies had shown that the polypeptide is an antagonist to activin. Moreover apart from being an antagonist to activin, Follistatin inhibits activities of other TGF-beta ligand such as GDF-11, BMP-2,-4,-6 and myostatin among others. In most cases, Follistatin is expressed in the ovaries, pituitary gland, and endometrial cells in some cases.
Follistatin 344 Chemical Profile
Molecular weight: 2888.16