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Frag 176-191

Frag 176-191 2mg

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  • Frag 176-191 2mg
  • Frag 176-191 5mg peptide

Frag 176-191

Availability: In stock

$17.99

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$17.99
Description

What is Frag 176-191?


All the information below is strictly for research purposes only. Under no circumstance should this chemical be used for human consumption.


Frag 176-191 is a modified amino acid sequence of growth hormone. The lipolytic activity of Frag 176-191 was confirmed by several published studies. The compound acts directly on the adipose fat tissues, increasing lipolysis and decreasing lipogenesis. Studies are being conducted on the compound since the early 1970’s. Frag 176-191 is rich in proline and proteases, as reported by a study published in 1984. Although, the compound mimics the properties of growth hormones, the former do not influence blood glucose levels. The compound’s molecular mass is 1871.1 and molecular formula is C78H125N23O23S2. The polypeptide is the most active part in the long HGH polypeptide chain.


The fragment is less than ten percent of the total size of GH; researchers have found the properties of the fragment to be effective in lipolysis as it mimics the activity of the natural growth hormone. The mechanism of action is through inhibition of lipogenesis while encouraging lipolysis. Moreover, it has no effect on the levels of insulin like growth factors. Fragment 176-191 exhibits high ability to burn stubborn adipocytes while increasing muscle mass, energy expenditure, and oxidation of fats.  The segments of the synthetic peptide HGH 176-191 have shown considerable effects in increasing blood glucose with other fragments such as 172-191,178-191 and 177-191. Moreover, studies reveal that the functionality of the polypeptide does not only depend on the correct physical configuration but also the informational sequence of the polypeptide sequence. The cytoplasmic domain acts a hinge to support the two other domains, which enhances the binding sites of the polypeptides by presenting the active sites to ligand for high affinity binding.


Frag 176-191 Chemical Profile


Formula: C78H125N23O23S2
Molecular weight: 1817.12
Peptide purity: > 99.0%
Chain:H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH


Click here to read more about Frag 176-191



What is Frag 176-191?



Frag 176-191 is a modified amino acid sequence of growth hormone. The lipolytic activity of Frag 176-191 was confirmed by several published studies. The compound acts directly on the adipose fat tissues, increasing lipolysis and decreasing lipogenesis. Studies are being conducted on the compound since the early 1970’s. Frag 176-191 is rich in proline and proteases, as reported by a study published in 1984. Although, the compound mimics the properties of growth hormones, the former do not influence blood glucose levels. The compound’s molecular mass is 1871.1 and molecular formula is C78H125N23O23S2. The polypeptide is the most active part in the long HGH polypeptide chain.



The fragment is less than ten percent of the total size of GH; researchers have found the properties of the fragment to be effective in lipolysis as it mimics the activity of the natural growth hormone. The mechanism of action is through inhibition of lipogenesis while encouraging lipolysis. Moreover, it has no effect on the levels of insulin like growth factors. Fragment 176-191 exhibits high ability to burn stubborn adipocytes while increasing muscle mass, energy expenditure, and oxidation of fats. The segments of the synthetic peptide HGH 176-191 have shown considerable effects in increasing blood glucose with other fragments such as 172-191,178-191 and 177-191. Moreover, studies reveal that the functionality of the polypeptide does not only depend on the correct physical configuration but also the informational sequence of the polypeptide sequence. The cytoplasmic domain acts a hinge to support the two other domains, which enhances the binding sites of the polypeptides by presenting the active sites to ligand for high affinity binding.



Research on fragment 176-191



There have been numerous studies that have been conducted on growth hormone and it is imperative that Frag 176-191 has a similar configuration to growth hormone. However, the most active part is located from amino acid 176 to amino acid number 191. Since the most active part is located on one end of the peptide that contributes hardly ten percent of the total size of growth hormone, it is very active. This part is very active because it can penetrate through cells and accentuate release of growth hormone from the pituitary gland. In order for you to understand how growth hormone is produced from the somatotrophs is imperative to note the somatotrophs are tiny cells that aid in releasing growth hormone from anterior lobe of pituitary gland. release of growth occurs in tandem with somatostatin and it is vital to note that when the production of growth hormone is high , production of somatostatin is low and vice versa. This is the main reason why researchers are looking for avenue of using exogenous peptides to accentuate release of growth hormone from anterior lobe of pituitary gland.



Peptide formation usually occurs when a carboxyl end of one amino acids combines with an amine group of another amino acid. Bond formation is vital because it determines configuration and how the peptide will work in accentuating release of growth hormone. Peptide formation plays a role in presentation of binding sites and this in turn accentuates release of growth hormone from anterior lobe of pituitary gland. Weight loss is achieved when Frag is administered to a biological system. This is seen to be effective because it prevents the formation of glycogen from high level of glucose in a biological system. However, it is imperative to note that the main cause of obesity is failure of receptors to note the presence of leptin. Leptin is an essential hormone that signals satiety in an organism, failure of the organism to respond to leptin it leads to obesity. It is imperative to note that fat deposition occurs because the cells cannot respond to a feeling of satiety.



Satiety is important because the test subject will not consume more calories than the recommended calories. Studies reveal that failure of response to leptin leads to an enhanced conversion of glucose to glycogen. Lipogenesis increases with time because the peptide leptin is in a low amount. Studies done on mice shows that Frag 176-191 has the ability to induce fat loss and it inhibits lipogenesis or formation of lipids from excess glucose in the system, Frag has ability to increase fat burning process. Glycogenesis is the formation of glycogen from glucose and it is this process that contributes to deposition of fats on the visceral and peripheral layer. The ability to induce reduction of fats on visceral and peripheral organs is largely contributed to the presence of Frag peptide. Frag peptide mimics the natural process of fat metabolism. Fat metabolism or beta-oxidation is essential in burning of fats to acetyl CoA and urea. Frag 176-191 is effective in accentuating lipolysis and studies reveal that it is 12.5 times more effective than a natural hormone.



Studies shows that once the peptide was administered on the test subjects, it showed at a quite significant effect on weight reduction. Daily monitoring of the parameters to monitor any rapid change in the system or any external factors interfering with the progress of the experiment. The main contributor of weight is impaired lipolytic system and it his context the fat cells will not respond to hormones and cellular multiplication is increased. Studies shows that Frag peptide is effective in preventing formation of newer fat cells in the system and this will prevent deposition on peripheral and visceral organs. Recent studies show that administration of the peptide helps in accentuating release of growth hormone, which in turn prevents formation of fat cells. Scientists injected Frag peptide on one-week-old mice and findings were taken on a daily basis. According to this research Fragment, 176-191 is vital in elucidating weight loss. Findings show that it is vital in inhibiting formation of fat cells.



Currently fragment peptide is available in kits and depending on the objective of the study, you should administer it consistency to attain a reproducible results. Frag 176-191 is crucial in stimulating a desired function in a biological system as it stimulates release of growth hormone in a continuous pulse and consistency is key for any research. Studies show that the peptide must be administered before the test subjects are fed or undertaken for certain exercises. It is imperative to note that Frag 176-191 stimulates release of growth hormone from anterior lobe of pituitary gland. In addition, peptide reconstitution should be done using bacteriostatic or saline water to avoid contamination or transfer bacterial from one end to another. Frag 176-191 is supplied in freeze-dried vial and it is imperative that you refrigerate the vial to avoid contamination and lowering peptides efficacy and potency. An aqueous solution should be prepared for one study and do not prepare too much peptide then store for next research. This will affect peptide integrity, because the amino acids in this peptide are prone to temperature and pressure changes. Refrigerate any excess amount to avoid contamination or reduction in functionality of amino acids of the peptide.



The most important aspect in research is that you should leave the peptide to thaw at room temperature because



When reconstituting Frag peptide always removes from the freezer then allows it to thaw at room temperature. This is essential because raising a temperature of Frag peptide rapidly will result in denaturation of bonds that in turn will cause failure of receptors to bind to Frag peptide. Fragment 176-191 is supplied with reconstitution information and it is crucial that you follow the information to the latter to avoid any contamination or poor reconstitution process. Recent studies show that it functions to by inhibiting transfer of nutrients and blood the fat cells or adipocytes. Failure of nutrient and blood supply to the target peptide means that the they die of malnourishment. It is imperative to note that with constant cellular death weight loss occurs in a biological system. According to the study administration of Frag, peptide on the test subject showed a reduction in serum glucose plasma and insulin levels. In addition, this peptide works in synergy with other molecules such as fragment 172-191, 178-191 among others. The functionality and efficacy of Frag 176-191 depends on the lead sequence or what is scientifically referred as informational sequence.



Informational sequence must be presented in the right order and binding will occur effectively thereby reducing the error of receptor and ligand low affinity. It is imperative that the informational sequence aids in binding of the peptide to proteases. Binding to proteases and other areas rich in proline changes the conformation of the fragment and it is important in causing positive feedback systems on cytoplasmic band 3. This band is crucial because it accentuates the transfer or molecules from one area to another. In addition, it increases affinity of Frag peptide. In addition, the conformation change is crucial because it increases the vitality and the efficacy. Recent studies show that Frag 176-191 does not increase glucose levels on the system. Moreover, findings show that it does not compete with human growth hormone for receptors on the anterior lobe of pituitary gland or in other parts of the biological system. Findings indicate that it has a positive feedback mechanism in preventing mass wasting and lypodystrophy.






 

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