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GHRP-2

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GHRP-2

Availability: In stock

$20.99

Availability: In stock

$20.99
Description

What is GHRP-2?


All the information below is strictly for research purposes only. Under no circumstance should this chemical be used for human consumption.


GHRP-2 is a growth hormone releasing polypeptide with short half-life. GHRP-2 consists of 6 amino acids. GHRP-2, a hexapeptide tend to influence G-protein coupled receptors. GHRP-2, also called KP-102, might increase IGF-1 levels. Research evidence published in the Journal of Endocrinology and Metabolism suggest that administration of GHRP-2 to growth hormone deficient individuals has increased plasma growth hormone levels. The synthetic version of GHRP-6 augments the hypothalamic activities and stimulates the pituitary gland to release growth hormones. The compound partially induces secretion of prolactin, ACTH and cortisol levels. By increasing calcium ion influx into the cells, the synthetic molecule facilitates growth hormone release. Studies are being conducted to assess the anti-inflammatory effects of GHRP-2. The compound’s molecular weight is 817.97 and molecular formula is C45H55N9O6.


GHRP-2 is a 2nd generation GHRP just behind growth hormone releasing hormone hexapeptide it is more superior in terms of hormonal stimulation and it acts for a long time while maintaining maximum level of GH in the serum. Moreover, it increases IGF-1 levels in the blood serum. Working synergistically with Ghrelin, GHRP-2 increases the number of somatotropes involved in the secretion of growth hormone. GHRP-2 has a short half-life with peak concentrations ranging between 15-60 minutes. In the response of the physiologic system, there is an increase in the levels of ca2+ in the serum, which is an ultimate response to the release of human growth hormone in high amplitude. Moreover, studies reveal that GHRP-2 is not lipogenic therefore; it does not induce storage of fats in the peripheral cells. Although the hormone may accentuate the release of Ghrelin, it does not necessarily play a direct role in inducing hunger.


GHRP-2 Chemical Profile


CAS: 158861-67-7
Formula: C45H55N9O6
Molecular weight: 817.9
Peptide purity: > 99.0%
Chain: D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH2




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What is GHRP-2?



GHRP-2 is a growth hormone releasing polypeptide with short half-life. GHRP-2 consists of 6 amino acids. GHRP-2, a hexapeptide tend to influence G-protein coupled receptors. GHRP-2, also called as KP-102, might increase IGF-1 levels. Research evidence published in the Journal of Endocrinology and Metabolism suggest that administration of GHRP-2 to growth hormone deficient individuals has increased plasma growth hormone levels. The synthetic version of GHRP-6 augments the hypothalamic activities and stimulates the pituitary gland to release growth hormones. The compound partially induces secretion of prolactin, ACTH, and cortisol levels. By increasing calcium ion influx into the cells, the synthetic molecule facilitates growth hormone release. Studies are being conducted to assess the anti-inflammatory effects of GHRP-2. The compound’s molecular weight is 817.97 Daltons and molecular formula is C45H55N9O6.



GHRP-2 is a 2nd generation GHRP just behind growth hormone releasing hormone hexapeptide it is more superior in terms of hormonal stimulation and it acts for a long time while maintaining maximum level of GH in the serum. Moreover, it increases IGF-1 levels in the blood serum. Working synergistically with Ghrelin GHRP-2 increases the number of somatotropes involved in the secretion of growth hormone.GHRP-2 has a short half-life with peak concentrations ranging between 15-60 minutes. In the response of the physiologic system, there is an increase in the levels of ca2+ in the serum, which is an ultimate response to the release of human growth hormone in high amplitude. Moreover, studies reveal that GHRP-2 is not lipogenic therefore; it does not induce storage of fats in the peripheral cells. Although the hormone may accentuate the release of Ghrelin, it does not necessarily play a direct role in inducing hunger.



Recent studies show that the peptide has various beneficial properties that if implemented it will make it one of the best peptides in the market. Some of potential benefits include reduction in adiposity, promotion of lean body mass, and anti-lipogenic properties. All these properties are essential inn accentuating various scientific processes. Subsequent research studies shows that GHRP 2 does not have any relationship with other growth hormone secretagogues such as CJC 1295 and sermorelin. All these hormones are important in accentuating production of growth hormone from somatotrophs but are not alike in any way. The peptide interacts with ghrelin a hormone that is widely known for accentuating gastric motility and gastric emptying. Gastric motility and gastric emptying are two aspects that are essential for weight loss to occur. According to the study when ghrelin hormone is accentuated it has antilipogenic properties, which ensures that the test subject does not consume a higher amount of food therefore no deposition of fats.



Ghrelin has a positive feedback mechanism on growth hormone and it increases production of growth hormone by reducing somatostatin pulses. Diminishing somatostatin pulses is key for any growth hormone to be produced in large quantities. Somatostatin is produced in pulses alongside growth hormone on the anterior lobe of pituitary gland. it is imperative to note that release of somatostatin occurs with growth hormone at the same time and reducing growth hormone leads to an increase in somatostatin and vice versa. Research is solely focused in looking for ways of reducing somatostatin and enhancing growth hormone. Ghrelin reduces activities of somatostatin while enhancing that of growth hormone, this is a crucial concept because enhanced growth hormone production leads to better cell division, development and maturity. Cellular division is crucial because the organism should be able to replace dead cells with new ones. In addition, recovery from injuries is enhanced because of a better functionality.



It is important to understand that GHRP 2 is a synthetic version of growth hormone secretagogue and it is supplied in the market solely for research purposes. This was the first secretagogue hormone synthesised before scientists came up with GHRP. The peptide has the same effect as growth hormone releasing hexapeptide but it does not affect the levels of cortisol, PRL and ACTH in a biological system. When growth hormone released is induced by GHRP 2, the natural response system increases amount of plasma calcium and this is vital in increasing levels of ghrelin and as indicated earlier ghrelin reduces activity of somatostatin and therefore increase GH secretion per cell. Studies reveal that GHRP 2 is more effective than GHRP 6 because it can produce growth hormone in large quantities and at a steady pace. In addition, research shows that it has a better half life than endogenously produced growth hormone. Laboratory studies reveal that it increases the level of insulin like growth factor 1 and it induces hormonal production with an enhanced capacity. Somatostatin cells release the peptide and it is crucial that its activity should be curtailed to avoid low production of growth hormone.



Unlike ghrelin hormone, GHRP 2 does not promote lipogenesis. Lipogenesis is the formation of fat cells on the peripheral and visceral organs resulting from rapid deposition. This means that GHRP 2 does not induce weight gain nor does it enhance gastric emptying in any way. However, it is imperative to note that GHRP 2 does not promote lipogenesis. It is an essential component in combating fat deposition on peripheral and visceral organs. Ghrelin is the main hormone that accentuates a feeling of hunger by increasing gastric motility and gastric emptying. In a physiological system, the activities of growth releasing factors inhibited at receptor level and recent research studies indicate that intake of growth hormone is mediate by neurons in the arcuate region and NPY/agouti gene. The main function of the peptide is to accentuate the production and secretion of growth hormone from pituitary gland. Pituitary gland plays a myriad of functions some of which includes pain relief, homeostasis, blood pressure, temperature regulation and growth. The peptide is crucial in increasing the production of growth hormone from somatotrophic ells and this is vital in promoting protein synthesis.



Increase in production of growth hormone can be attributed to a wide array of factors one of the main factors is the reduction of somatostatin activity. This peptide is vital for regulating the endocrine system and it affects neurotransmission, cell proliferation via G-coupled proteins. The peptide increases the level of insulin like growth factor an essential compound in accentuating growth hormone production. This protein is found in the liver and it is important in repair of cells and muscle tissues. Moreover, it increases the influx of calcium ions in the system thereby promoting tissues development. One of the main aspects is that GHRP-2 does not induce hunger by itself. However, it increases production of ghrelin. When ghrelin is produced in a biological system, it increases gastric motility and gastric emptying. Ghrelin peptide is made up of twenty-eight amino acids and it is produced by epsilon cells located in the stomach and pancreas. The peptide has positive feedback mechanism on growth hormone. When amount of ghrelin is increased in the system, there is a rapid increase in a feeling of hunger. According to research when the mice were injected with the peptide, there was a sudden increase in the amount of food ingested. An increase in food intake initiates compensation elevated function and this will bring about homeostasis and eventually increase protein synthesis.



Research has shown that the peptide has several potential benefits. As per studies, the mice showed an increase in the rate of food breakdown and it promoted lean body mass. In some scenarios, the peptide lowered cholesterol levels and improved bone density a concept that is closely monitored by researchers. On the contrary, it is imperative to note that there are potential side effects as well, according to studies, the peptide increased water retention, fatigue, reduced insulin sensitivity and it led to development of carpal tunnel type symptoms. Research shows that an increase in ghrelin levels in the system is an essential aspect because it increase fat burning abilities of the peptide. The synthetic version has enhanced bioavailability and there is evidence to prove that it is better than its predecessors are. There is enough data to prove that only GHRP 2 administered peripherally promoted lean body mass, increased protein intake and it enhanced muscle development. The peptide plays a vital role in increasing amount of growth hormone and it is important to note that cellular proliferation and multiplication.



Hormonal regulation of food intake can be classified as short term or long-term signals, which include insulin and leptin for long term and ghrelin, PYY and cholecystokinin for short term. Released ghrelin works on NPY-AGRP neurons and it is activated when it reaches the arcuate nucleus. The most essential aspect in research is to understand how the hormones circulate and how they reach hypothalamic neurons. Central administration f the peptide increases spontaneous variation and the endogenous amounts of ghrelin will affect diurnal meal times. Moreover, postprandial suppression of ghrelin is equivalent to the meal taken. Scientific data shows that GHRP 2 elicits anorexic properties and acute change in food intake in research mice. Ghrelin has a huge magnitude of downstream effects on peripheral and nervous receptors and studies have revealed that it could prove useful in alleviating various conditions. It is imperative to note that all peptides supplied are for research purposes only and human consumption is prohibited.




 

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