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GRF 1-44

GRF 1-44

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GRF 1-44

Availability: In stock

$45.99

Availability: In stock

$45.99
Description

What is GRF 1-44?


All the information below is strictly for research purposes only. Under no circumstance should this chemical be used for human consumption.


The primary function of GRF 1-44 is to stimulate growth hormones release via the pituitary gland. GRF 1-44 contains 44 amino acids. The hormone is secreted in the arcate nucleus of the hypothalamus. It is hypothesized that GRF 1-44 may enhance IGF-1 release, immune functions and sleep. Upon release into the pituitary portal circulation, GRF 1-44 promotes growth hormone biosynthesis and release from the somatotrophs. By negative feedback inhibition, the compound influence growth hormone neuroendocrine axis and release of somatostatin. The release of GH is dependent on a cAMP-dependent pathway although in some instances the production may go through the phospholipase C pathway among other pathways. The cyclic AMP dependent pathway is initiated when the receptors changes its conformation, this in turn causes the activation of G –alpha sub unit of the G-protein complex. When the G-alpha sub unit is activated, it stimulates the adenylyl cyclase, this is membrane bound, and it increases the cyclic AMP. 


GRF 1-44 release to the bloodstream stimulates the production of growth hormone from the somatotrophs in the pituitary gland. The hormone is an endogenous hormone and it is essential in accentuating the release of GH and inhibiting the activities of somatostatin. Recent studies indicate that the hormone is vital in promoting slow wave sleep; the receptors are specific to the hormone and function effectively when in conjunction with Ghrelin. The GRF 1-44 has a very short half life after its release from the anterior lobe of the pituitary gland. Studies have shown that GRF 1-44plays a very crucial role in the production of growth hormone. GHRH accentuates the production of GH by binding to GHRH receptor GRFR on the cells .


GRF 1-44 Chemical Profile


CAS: 90599-39-6


Formula: C215H358N72O66S1


Molecular weight: 5039.65


Peptide purity: > 99.0%


Chain: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2



What is GRF 1-44?



The primary function of GRF 1-44 is to stimulate growth hormones release via the pituitary gland. GRF 1-44 contains 44 amino acids. The hormone is secreted in the arcuate nucleus of the hypothalamus. It is hypothesized that GRF 1-44 may enhance IGF-1 release, immune functions, and sleep. Upon release into the pituitary portal circulation, GRF 1-44 promotes growth hormone biosynthesis and release from the somatotrophs. By negative feedback inhibition, the compound influence growth hormone neuroendocrine axis and release of somatostatin. The release of GH is dependent on a cAMP-dependent pathway although in some instances the production may go through the phospholipase C pathway among other pathways. The cyclic AMP dependent pathway is initiated when the receptors changes its conformation, this in turn causes the activation of G –alpha sub unit of the G-protein complex. When the G-alpha sub unit is activated, it stimulates the adenylyl cyclase, this is membrane bound, and it increases the cyclic AMP. GRF 1-44 release to the bloodstream stimulates the production of growth hormone from the somatotrophs in the pituitary gland.



The hormone is an endogenous hormone and it is essential in accentuating the release of GH and inhibiting the activities of somatostatin. Recent studies indicate that the hormone is vital in promoting slow wave sleep; the receptors are specific to the hormone and function effectively when in conjunction with Ghrelin. The GRF 1-44 has a very short half-life after its release from the anterior lobe of the pituitary gland. Studies have shown that GRF 1-44plays a very crucial role in the production of growth hormone. GHRH accentuates the production of GH by binding to GHRH receptor GRFR on the cells. Studies indicate that GRF 1-44 has a higher potency and efficacy in accentuating its functionality of release growth hormone from anterior lobe of pituitary gland. The synthetic version has a short half-life when compared to naturally produced hormone. It is imperative to note that the mode of administration affects efficacy and potency of this peptide. It is crucial to administer using a method that will increase its bioavailability and functionality. Contrary to the commercially produced peptides GRF 1- 44 has undergone several modifications that increase its half-life, orientation of receptor ligand and chemical reactions to boost its half-life.



Modifications on the peptide are crucial because bioavailability of the peptide plays an essential role in research. You can administer a high volume of the peptide but the reaction and findings are slow or none. It is imperative to note that administration of the peptide should increase its availability in the system and present all the receptors in the right angles to accentuate growth and development. In any biological system, binding of ligand to receptor is important because it determines how effective the peptide will be in presenting its activity. Synthetic peptides are able to travel long distances in a biological system because they have been modified to traverse different parts of the body with ease while still maintaining its activity. This is essential because a common problem with endogenous hormone is that it is affected by a higher concentration of enzymes that degrade its activity.



Release of growth hormone usually occurs in pulses on the anterior lobe of pituitary gland and it is released alongside somatostatin. Studies reveal that increase the pulse of one peptide leads to a reduction in another peptide. Degradation, denaturation, and loss of activity are some of challenges that occur when using an exogenous peptide. Recent studies show that GHRH plays an important role in slow wave sleep; this means that the peptide could be used to accentuate sleep. Growth hormone is present in minute amounts in blood serum and plasma. Concentration of the hormone in the brain varies depending on its mode of administration among other factors. GHRH plays an essential role in enhancing circadian rhythm. This means that it works well in research subjects by improving the sleep. According to research, concentration of this hormone is low in the morning and it peaks at night. An elevated level of GHRH is known to induce slow wave sleep and rapid eye movement. These two features are associated with deep sleep. Plasma concentration of growth hormone releasing hormone is seen to play a role in inducing sleep mode.



Studies reveal that GRF 1-44 provides a new frontier in understanding some conditions such as Cushing’s syndrome and the induction of slow wave sleep. However, it is vital to note that the peptides are still under research and further modification of these peptides will lead to development of a better frontier in science. One of the unique features about growth hormone releasing hormone is that it is able to cross blood brain barrier and does not undergo any kind of degradation therefore bringing a new aspect in research and development. The presence of growth hormone releasing hormone is in high concentration of the subject’s brain during the night and this is known to promote slow wave sleep. According to recent research study done on radioimmunoassay technique the half-life of GRF 1-44 is about 7-9 minutes and this is very short considering the fact that the peptide travels a long distance for it to accentuate a certain feature.



In situations where the peptide interacts with other drugs in the system, it is metabolized by peptidases present in the system. Internal mechanisms, which control sleep, have been an area of interest for many scientists and it is important to note that many researchers are trying to find how the mechanism works. Some of the peptides that function in a biological system include CCK or cholecystokinin and prostaglandin among others. Most humoral mediators have a relationship in inducing sleep and affecting how circadian rhythm works. Since growth hormone releasing hormone was discovered there have studies conducted to see if the peptide could be used to pressure the test subject to sleep by administering exogenous peptide. However, it is still under research and investigation and human consumption is not allowed. Growth hormone releasing hormone is touted as a major sleep promoting hormone and confusion should be cleared that some people are calling it a sedative. The modulator effects on wake, sleep functions is still under research, and the research studies are trying to identify its activity and how it manages to carry out certain functions.





According to studies, subjecting mice to growth hormone releasing hormone resulted in a deep and longer sleep than a regular sleep. It is therefore imperative to note that the peptide could be used to induce sleep in test subjects. Even when the mice were disturbed during their sleep, they got back to sleep immediately. This showed how effective the peptide is in accentuating sleep. There are subsequent research studies geared towards understanding its principle of action and how it can be utilized to induce sleep. It is imperative to note that peptides supplied in the market are solely for research purposes and human consumption is not allowed. Growth hormone releasing hormone is known to have a net positive effect in inducing growth of nascent to mature cells. It is essential to understand that it can accentuate the production of new cells to replace the dead one or to alleviate emaciated one. When hormone level rises in blood, it increases the level of cyclic adenosine monophosphate.



An increase in cyclic adenosine monophosphate is important in inducing activities of protein kinase A, this allows the cyclic adenosine monophosphate to bind to cyclic adenosine monophosphate response element protein, or what is called CREB. This occurs when a phosphate group is added to the molecule and the addition of a phosphate molecule results in induction of a signaling that will increase transcription factors that are important in promoting cell division. On the other hand, production of the hormone via phospholipase C pathway is essential for cell division, cell multiplication, and maturity. This is important for cell repair and growth to occur. The main aim is the activation of PLC or phospholipase pathway via several beta G-proteins. This in turn activates phospholipase pathway and it produces calcium ions on the endoplasmic reticulum. Activated phospholipase pathway leads to production of growth hormone from anterior lobe of pituitary gland. Channels release growth hormone via calcium ion-dependent channel and this increase hormonal production.



Growth hormone releasing hormone is essential in accentuate the release of growth hormone from somatotrophs or cells that release GH from pituitary gland. Discovery and characterization of peptide cannot be underestimated especially in modern research and a reduction of growth hormone releasing hormone is seen to reduce amount of growth hormone released per cell. Failure to respond to production of growth hormone from the anterior lobe of pituitary gland means that the peptide release is affected and in most cases, stunted growth occurs. Identification of the peptide is vital in understanding various aspects of research. Moreover, current science shows that the peptide could be produced using other channels when the pathway is activated and GRF 1-44 is the best peptide to accentuate its release. The efficacy and potency of these peptides are still under research and human consumption is not allowed. In most cases, the supplied peptide is solely for research purposes only.