Ipamorelin, also called as NNC 26-0161, is a pentapeptide, Ghrelin receptor agonist, and selective secretagogue of growth hormones. The short chain peptide contains five amino acids with a long half-life. Ipamorelin demonstrated significant growth hormone releasing capability in experimental studies including in vivo and in-vitro. The action of Ipamorelin mimics GHRP-6 promotes growth hormone release from the pituitary cells by acting on GHRP-like receptors. Studies suggest that the compound did not influence cortisol or ACTH levels. Ipamorelin is being studied extensively by the biomedical researchers due to high specificity. The molecular weight and formula of Ipamorelin is 711.85 Daltons and C38H49N9O5.Just like GHRP-2 and GHRP-6 ipamorelin suppresses the action of somatostatin and stimulate the production and secretion of GH. Ipamorelin the third generation of the GHRPs, however, it is more enhanced than its predecessors and has a longer half-life.
Research indicates that ipamorelin mainly acts by activating specific G-protein secretagogues, which in turn increases gastric emptying and gastric motility. The major target for the hormone is the anterior lobe of the pituitary gland where it induces the release of growth hormone, recent studies show that the hormone has no effect on the level of luteinizing hormone, PRL, follicle stimulating hormone and thyroid stimulating hormone. The GRLN receptor is responsible for the activation of tiny molecules on the pituitary gland, which in turn brings the release of growth hormone. Ipamorelin is known to act on the same receptor that GH acts on, however, somatostatin hinders the production and secretion of GH since they are produced in pulses. An increase in the concentration of the polypeptide allows the hormone to be produced in a continuous flow and therefore inducing cell division, proliferation, differentiation, development and maturity thereby bringing about growth and development. D-Lys3-GHRP-6 is the only antagonist to the hormone since it denatures receptor sites, therefore, the hormone cannot bind to the desired ligand.
Ipamorelin was discovered in early 1990 by researchers who wanted to understand various aspects of the production of growth hormone from the pituitary gland. The mode of action of ipamorelin and research studies shows that the peptide has and it has since attracted a huge buzz in the research society. Recent studies reveal that the mode of action of ipamorelin peptide is just like that of growth hormone releasing peptide 2. However, it is essential to note that ipamorelin does not have hunger-stimulating properties because it does not accentuate release of peptide ghrelin. Moreover, it is important to note that ipamorelin does not have lipogenic properties and it works in synergy with other molecules to accentuate release of growth hormone from the pituitary gland. Hormonal production in a biological system is limited to other factors such as enzymes, inhibitors among others.
It is imperative to note that somatostatin is produced in the same cells as the growth hormone and when production of one hormone is at highest, the other one is at lowest. Reducing activity of somatostatin is important in the accentuating release of growth hormone in large pulses. Somatotrophs respond to different factors among them growth hormone releasing hormone and other peptides that mimic the activity of the growth hormone releasing hormone. Ipamorelin peptide increases production of growth hormone from pituitary gland by increasing the amount of hormone produced per cell. Growth hormone releasing hexapeptide has similar properties to ipamorelin in that they both accentuate production and release of growth hormone from the anterior lobe of the pituitary gland. Growth hormone releasing hormone is known to increase the levels of prolactin and cortisol in a biological system. However, hexarelin, on the other hand, have activities in increasing among of ghrelin in the system. Hexarelin is a growth hormone that has similar properties to that of ipamorelin and they are both stable forms of ghrelin.
Ghrelin is a peptide that is important in increasing gastric motility and gastric emptying. Research shows that these peptides influence activities of insulin-like growth factor 1. Nevertheless, ipamorelin is known to increase the levels of acetylcholine in the system and this is a crucial aspect because acetylcholine is used in neurotransmission. Cell to cell communication plays a vital role in accentuating presentation of information in different cells of a biological system. Recent studies show that ipamorelin works by increasing activities of G-coupled protein-coupled receptor secretagogues, these increases gastric motility, gastric emptying. The main target of the hormone is the anterior lobe of pituitary gland. Studies show that ipamorelin does not affect the levels of TSH, FSH, LH and PRL in the plasma. Growth hormone releasing hormone receptors are called GRLN and they work by activating minute compounds on the pituitary glands to release growth hormone.
Cell multiplication is an important factor, which helps in repairing damaged cells and tissues and in most cases, it enhances tissue development. Ipamorelin is vital because it carries out important activities in the cytoplasm. Research studies reveal that the peptide is one of the cleanest and safest growth hormone releasing peptide. According to findings from these studies, ipamorelin plays a role in enhancing sleep patterns. Mice were injected with the peptide and their sleeping patterns monitored results shows that a dose of 1.2 mg per day is essential in elucidating a wide array of effects in a biological system. It is important to understand that even with elevated levels of the peptide release of growth hormone from somatotrophs. However, there is a level that even when the administration of peptide ipamorelin is increased it does not affect the release of growth hormone from pituitary gland. The mechanism of action of this peptide is still under investigation in determining its efficacy and potency in releasing growth hormone.
Studies reveal that ipamorelin has no effect on accentuating hunger because the peptide does not promote the production of ghrelin. Ghrelin accentuates gastric motility and gastric emptying. Administering ipamorelin to the system is crucial to enhance growth hormone released per cell and somatotrophs on anterior lobe of pituitary gland have increased considerably. Somatotropes synthesize growth hormone and the pulse can stay active for three hours after administration of the peptide. Once it is synthesized it is then ferried to different cells in the system via the bloodstream and studies shows that the efficacy and potency of the peptide largely depend on configuration. Ipamorelin peptide does not interfere with bone cartilage and myoblastic differentiation on the cells. Muscle movement is enhanced especially with the movement of the peptide from one end of a biological system to the other. It is imperative to note that the peptide is touted as one of the most effective peptides in the accentuating release of growth hormone from somatotrophs on the anterior lobe of pituitary gland.
Lean body mass is vital in accentuating formation of myoblasts which in turn enhances muscle vitality and strength. Ipamorelin peptide is crucial in enhancing cell synthesis, development, and maturity. In addition, an elevated level of ghrelin and insulin in the stomach is crucial in enhancing shuttling processes across a biological system. Although some studies deem the activity of ipamorelin as mild, studies have shown that it can induce a higher performance and it could help in alleviating muscle atrophy and muscle fatigue experienced. Just like any other peptide when conducting research it is vital that you keep the peptide in a cool environment free from any contamination and bright light. This is important because the mode in which peptides blend is vital for functionality to occur. You can keep the peptide in a fridge or at room temperature when reconstituting. It is vital that you use saline or bacteriostatic water during reconstitution process. This peptide plays a crucial role because using any contaminated substance will affect purity and integrity of ipamorelin.
Ipamorelin works in synergy with other peptides to accentuate the release of growth hormone from the anterior lobe of pituitary gland. Various studies are being conducted to determine the efficacy and potency of this peptide. Ipamorelin is classified as an agonist to peptides that accentuates the release of growth hormone from pituitary gland. Studies conducted on mice shows that it has a positive feedback mechanism on the thyroid gland. Enhancing thyroid gland secretion is vital for the overall functionality of the peptide. The mice on research study should be checked regularly, this is essential because studies cannot be used as a benchmark if the findings cannot be reproduced in another setting. In addition, ipamorelin has the ability to boost production of insulin-like growth factor 1 an essential component in cell repair and production of other cells.
Studies done on injured mice shows that this peptide has the power to accentuate release of growth hormone and it promotes lean body mass while enhancing the functionality of muscles. In addition, it does not affect the cartilage and although there might be a few side effects such as site reactions, nausea, vomiting and other minor side effects, ipamorelin is one of the most effective peptides in the accentuating release of growth hormone from somatotrophs. There are studies that are being conducted to determine the efficacy and potency of the peptide in the accentuating release of growth hormone.