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Myostatin HMP

Myostatin HMP

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Myostatin HMP

Availability: In stock

$128.99

Availability: In stock

$128.99
Description

What is Myostatin HMP?


All the information below is strictly for research purposes only. Under no circumstance should this chemical be used for human consumption.


Myostatin HMP, also known as growth differentiation factor 8 (GDNF-8) is a protein encoded by MSTN gene. Myostatin HMP is primarily synthesized in skeletal muscle cells and acts in muscle tissues. Myostatin HMP belongs to TGF-beta super-family and negative feedback regulator of skeletal muscle mass. In circulation, myostatin exists as latent myostatin propeptide that binds and inhibit myostatin in vitro. In vivo, myostatin propeptide is a negative regulator of myostatin. Recombinant myostatin propeptide contains 244 amino acids with a molecular mass of 27.8 kDa. Myostatin contains two identical subunits that consist of 109 amino acids. Myostatin occurs as inactive form and requires protease cleavage in NH2-terminal to be activated.


Myostatin binds with activin type-II receptor and recruits Alk-3 or Alk-4 that intiates cell signaling cascade in the muscles including SMAD family activation. Upon gene regulation and binding with myoblasts, myostatin prevents differentiation of premature cells into mature muscle cells.
Research studies suggest that Akt inhibits a causative kinase that involve in muscle hypertrophy by activation of protein synthesis. Myostatin acts in two ways either by inhibiting Akt-induced protein synthesis or by inhibiting muscle differentiation. The peptide is mainly produced in the skeletal muscles and it is circulated via blood. It acts by binding to the cell bound receptors, which is referred to, as activin type II receptor. As indicated earlier upon binding there is recruitment of co receptors, this co receptors begins the process of cell signaling cascade within the muscle cell, which in turn promotes myoblasts proliferation, development, and maturity. Moreover, myostatin is known to block Akt, a kinase that causes muscle hypertrophy.

Myostatin HMP chemical profile

Formula: C121H200N42O39
Molecular weight: 2888.16
Chain: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys